The present invention discloses a positioning method. When a primary cell PCell and a serving cell SCell that are of user equipment UE have different uplink-downlink configurations at a same subframe location, and the UE does not support simultaneous transmission and reception, the method includes: receiving, by a first device, positioning information of the UE, where the positioning information includes positioning assistance information, or positioning assistance information and a UE identifier, and the positioning assistance information includes at least positioning reference signal PRS information, or PRS information and a Cell ID; determining, by the first device and according to the positioning information, that the UE performs PRS measurement at the same subframe location of the SCell that has same configuration, and avoiding, by the first device, scheduling data or configuring a sounding signal sounding at the same subframe location of the PCell and the SCell that have different configurations.