A method in a radio network controller (130) is disclosed. The method comprises determining (1204) a decimation factor for a transmit power control (TPC) algorithm, the TPC algorithm comprising a power control algorithm according to which TPC commands for controlling a transmit power of a wireless device (110) are discontinuously transmitted to the wireless device by a network node (115), the decimation factor indicating a predefined number of slots, wherein one out of the predefined number of slots is for transmitting a TPC command to the wireless device; upon determining the decimation factor for the TPC algorithm, modifying (1208) one or more parameters related to TPC to optimize TPC using the TPC algorithm having the determined decimation factor; and configuring (1212) the network node to control the transmit power of the wireless device according to the TPC algorithm and the one or more modified parameters.