Invention Grant
- Patent Title: Inhibition of glutaminase C
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Application No.: US13259533Application Date: 2010-03-25
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Publication No.: US10532034B2Publication Date: 2020-01-14
- Inventor: Richard A. Cerione , Jon W. Erickson , Kristin Wilson Cerione , Jianbin Wang
- Applicant: Richard A. Cerione , Jon W. Erickson , Kristin Wilson Cerione , Jianbin Wang
- Applicant Address: US NY Ithaca
- Assignee: Cornell University
- Current Assignee: Cornell University
- Current Assignee Address: US NY Ithaca
- Agency: Pepper Hamilton LLP
- Priority: WOPCT/US2010/028688 20100325
- International Application: PCT/US2010/028688 WO 20100325
- International Announcement: WO2010/111504 WO 20100930
- Main IPC: A61K31/473
- IPC: A61K31/473 ; A61K31/00
Abstract:
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed and include those of formula (III): wherein B, R1c, R2c, m, and n are defined herein.
Public/Granted literature
- US20120220610A1 INHIBITIONS OF GLUTAMINASE C Public/Granted day:2012-08-30
Information query
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