Invention Grant
- Patent Title: Biophosphonate compounds and gamma delta T cell-mediated therapy for treating epstein-barr virus-associated disorders
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Application No.: US14824316Application Date: 2015-08-12
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Publication No.: US10532064B2Publication Date: 2020-01-14
- Inventor: Wenwei Tu , Zheng Xiang , Yinping Liu
- Applicant: The University of Hong Kong
- Applicant Address: HK Hong Kong
- Assignee: The University of Hong Kong
- Current Assignee: The University of Hong Kong
- Current Assignee Address: HK Hong Kong
- Agency: Pabst Patent Group LLP
- Main IPC: A61K31/663
- IPC: A61K31/663 ; C12N5/0783
Abstract:
Aminobisphosphonate pamidronate (PAM) can control Epstein-Barr virus (EBV) associated disorders in humanized mice through a Vγ9Vδ2-T-cell dependent mechanism. This suggests a strong potential for a therapeutic approach using PAM to boost human Vγ9Vδ2-T-cell immunity against EBV associated disorders, such as the lymphoproliferative disease (LPD), posttransplant lymphoproliferative disorder (PLPD), Hodgkin's disease, Burkitt's lymphoma, and nasopharyngeal carcinoma (NPC).
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