Invention Grant
- Patent Title: Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods
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Application No.: US15120798Application Date: 2015-02-27
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Publication No.: US10532088B2Publication Date: 2020-01-14
- Inventor: Gary D. Glick , Peter L. Toogood , Xiao Hu , Thomas D. Aicher , Laura Lee Celeste , Xikui Liu , Clarke B. Taylor , Chad A. Van Huis
- Applicant: Lycera Corporation
- Applicant Address: US MA Ann Arbor
- Assignee: Lycera Corporation
- Current Assignee: Lycera Corporation
- Current Assignee Address: US MA Ann Arbor
- Agency: Dechert LLP
- International Application: PCT/US2015/017977 WO 20150227
- International Announcement: WO2015/131035 WO 20150903
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61K31/4353 ; A61K31/437 ; A61K31/4375 ; A61K31/47 ; A61K31/4709 ; A61K31/538 ; C12N5/0783 ; A61K39/00 ; A61K35/15 ; A61K39/02
Abstract:
The invention relates to medical therapy using an agonist of the retinoic acid receptor-related orphan receptor gamma (RORγ) and provides adoptive cellular therapies using an agonist of RORγ, populations of lymphocyte cells that have been exposed to an agonist of RORγ, populations of dendritic cells that have been exposed to an agonist of RORγ, pharmaceutical compositions, and methods for enhancing therapeutic effects of lymphocyte cells and/or dendritic cells in a patient by administering an agonist of RORγ to a patient.
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