Invention Grant
- Patent Title: Cytomegalovirus vectors eliciting T cells restricted by major histocompatibility complex E molecules
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Application No.: US15786847Application Date: 2017-10-18
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Publication No.: US10532099B2Publication Date: 2020-01-14
- Inventor: Louis Picker , Scott Hansen , Klaus Frueh , Daniel Malouli , Jay Nelson , Jonah Sacha , Meaghan Hancock
- Applicant: Oregon Health & Science University
- Applicant Address: US OR Portland
- Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
- Current Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
- Current Assignee Address: US OR Portland
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: A61K45/00
- IPC: A61K45/00 ; A61K39/00 ; A61K39/12 ; C12N7/04 ; C12N15/86 ; C12N15/113
Abstract:
Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
Public/Granted literature
- US20180133321A1 CYTOMEGALOVIRUS VECTORS ELICITING T CELLS RESTRICTED BY MAJOR HISTOCOMPATIBILITY COMPLEX E MOLECULES Public/Granted day:2018-05-17
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