Invention Grant
- Patent Title: Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
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Application No.: US16271549Application Date: 2019-02-08
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Publication No.: US10532108B2Publication Date: 2020-01-14
- Inventor: Peter Dragovich , Zhonghua Pei , Thomas Pillow , Jack Sadowsky , Vishal Verma , Donglu Zhang
- Applicant: GENENTECH, INC.
- Applicant Address: US CA South San Francisco
- Assignee: GENENTECH, INC.
- Current Assignee: GENENTECH, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Viksnins Harris Padys Malen LLP
- Main IPC: A61K47/68
- IPC: A61K47/68 ; A61P35/00 ; A61K31/5517
Abstract:
The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.
Public/Granted literature
- US20190175749A1 PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF Public/Granted day:2019-06-13
Information query
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