A programming unit for TPMS sensors includes at least a microcontroller and memory storing at least a vehicle group database comprising multiple vehicle groups, each vehicle group comprising at least one vehicle, a version pair database comprising multiple version pair groups, each version pair group representing one vehicle group and comprising at least one version pair wherein each version pair includes an associated application version and an associated sub-application version, an application database comprising multiple application versions, each application version includes an associated binary file, and a sub-application database comprising multiple sub-application versions, each sub-application version includes an associated binary file.