A device for deterring drug abuse includes a housing configured to contain a drug accessible through an access port. The device includes a physical deterrent configured to move from an unsecured position, wherein the access port of the housing is normally accessible, to a secure position, wherein the access port of the housing is normally inaccessible. The device further includes a locking mechanism that is coupled with the physical deterrent. The locking mechanism has a locked mode, wherein the physical deterrent does not normally move from the secure position to the unsecured position. The locking mechanism is further coupled with a deterrent container having a deterrent substance. The device is configured such that attempts to access the drug when the physical deterrent is in the secure position, and when the locking mechanism is in the locked mode, activate the release of the deterrent substance to the drug.