Invention Grant
- Patent Title: Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
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Application No.: US15766736Application Date: 2016-06-30
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Publication No.: US10533011B2Publication Date: 2020-01-14
- Inventor: Long Mao , Jia Liu , Yile Chen , Yuning Hua , Kongen Dai , Yimei Bao , Bojie Weng , Xiaopeng Mo , Jian Wu , Xiao Xu , Wanhong Xu , Xiaobo Wang
- Applicant: ACEA THERAPEUTICS, INC.
- Applicant Address: US CA San Diego
- Assignee: ACEA THERAPEUTICS, INC.
- Current Assignee: ACEA THERAPEUTICS, INC.
- Current Assignee Address: US CA San Diego
- Agency: Rimon, P.C.
- Priority: WOPCT/CN2015/091536 20151009
- International Application: PCT/CN2016/087857 WO 20160630
- International Announcement: WO2017/059702 WO 20170413
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K9/48 ; A61K9/20
Abstract:
Provided are methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.
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