Invention Grant
- Patent Title: Method for manufacturing 7alpha-alkoxyoxacephem intermediate compound
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Application No.: US16108234Application Date: 2018-08-22
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Publication No.: US10533019B2Publication Date: 2020-01-14
- Inventor: Dong Chan Kim
- Applicant: DONGDO CO., LTD. , Tianjin GreenPine Pharma Co., Ltd.
- Applicant Address: KR Seoul CN Tianjin
- Assignee: DONGDO CO., LTD.,TIANJIN GREENPINE PHARMA CO., LTD.
- Current Assignee: DONGDO CO., LTD.,TIANJIN GREENPINE PHARMA CO., LTD.
- Current Assignee Address: KR Seoul CN Tianjin
- Agency: Norton Rose Fulbright US LLP
- Priority: KR10-2017-0117032 20170913
- Main IPC: C07D505/06
- IPC: C07D505/06 ; C07D505/20 ; C07D505/10 ; C07D498/04

Abstract:
The present disclosure provides a method for preparing a 7α-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solvent to form a reaction product such that unreacted halogen compound remains; and adding metal alkoxide and reducing agent to the reaction product with the unreacted halogen compound remaining, thereby to produce a compound represented by a following chemical formula 2: where R is a Cl, Br, I, halogen derivative, R1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H), and R2 is an alkyl group having 1 to 4 carbon atoms.
Public/Granted literature
- US20190077812A1 METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND Public/Granted day:2019-03-14
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