Invention Grant
- Patent Title: Method for producing polyploidized megakaryocyte and platelets
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Application No.: US15680920Application Date: 2017-08-18
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Publication No.: US10533185B2Publication Date: 2020-01-14
- Inventor: Koji Eto , Hiromitsu Nakauchi , Naoya Takayama , Sou Nakamura
- Applicant: The University of Tokyo
- Applicant Address: JP Tokyo
- Assignee: The University of Tokyo
- Current Assignee: The University of Tokyo
- Current Assignee Address: JP Tokyo
- Agency: Morgan, Lewis & Bockius LLP
- Priority: JP2011-108253 20110513
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N5/078 ; A61K35/19
Abstract:
An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
Public/Granted literature
- US20180016597A1 Method for Producing Polyploidized Megakaryocyte and Platelets Public/Granted day:2018-01-18
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