A system includes a manifold and a shared valve actuation system that is operatively coupled to the manifold at a single location. The manifold is comprised of a block with at least one drilled header hole formed within the block, a plurality of drilled flow inlet holes formed within the block, wherein the number of drilled flow inlet holes corresponds to the number of external flow lines that supply fluid to the manifold, and a plurality of isolation valves coupled to the block, the valve element for each of the isolation valves positioned within the block. The system includes an arm that rotates about an axis that is normal to an upper surface of the block of the manifold, a plurality of structural elements that are coupled to one another via rotary joints, and a tool that engages and actuates one of the plurality of isolation valves.