The present disclosure is directed to a method of manufacturing a modular rotor blade for a wind turbine. The method includes providing a plurality of resin systems for manufacturing a plurality of blade components for the modular rotor blade. Each of the resin systems includes at least one of a thermoset material or a thermoplastic material, optionally a fiber reinforcement material, and at least one additive. Thus, the method includes determining a resin system for each of the blade components based on a location and/or function of each blade component in the rotor blade. In addition, the method includes forming each of the blade components of the rotor blade from one of the plurality of resin systems and securing each of the blade components together to form the modular rotor blade.