Methods, devices, and systems for transmitting information using a unique word (UW) with discrete Fourier transform spread orthogonal frequency division multiplexing (DFT-s-OFDM) are described herein. In an example, a wireless transmit/receive unit (WTRU) may generate a reference sequence. Further, the WTRU may generate a DMRS sequence based on upsampling of the reference sequence. In an example, the DMRS sequence may include a plurality of repeating sequences. Further, in an example, each repeating sequence may include a head sequence, a reference sequences and a tail sequence. Also, a UW sequence within the DMRS may include one of the repeated head sequences and one of the repeated tail sequences. In addition, the WTRU may generate a DMRS signal based on a waveform operation on the DMRS sequence. The WTRU may then transmit the DMRS signal as a reference signal.