Invention Grant
- Patent Title: 2′-Fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
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Application No.: US15609080Application Date: 2017-05-31
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Publication No.: US10536415B2Publication Date: 2020-01-14
- Inventor: Chung K. Chu , Jianing Wang
- Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- Applicant Address: US GA Atlanta
- Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- Current Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- Current Assignee Address: US GA Atlanta
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: C07D473/18
- IPC: C07D473/18 ; A61K31/522 ; H04L12/58 ; A61K31/52 ; C07D473/34 ; A61K45/06 ; A61K31/675
Abstract:
The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.
Public/Granted literature
- US20180063059A1 2'-FLUORO-6'-METHYLENE CARBOCYCLIC NUCLEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS Public/Granted day:2018-03-01
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