An atrial fibrillation detection system and associated methods of use are disclosed for analyzing and identifying atrial fibrillation signs of a user. In at least one embodiment, the system includes an at least one computing device configured for receiving and processing an at least one biosignal associated with heart activity of the user as captured by an at least one beat detector, and subsequently transmitting said processed at least one biosignal, as a plurality of sequence segments, making up an at least one interbeat interval sequence of the biosignal, to an at least one classifier configured for determining a probability of the at least one interbeat interval sequence of the biosignal being an atrial fibrillation rhythm or a non-atrial fibrillation rhythm.