Self-describing calibration targets for inclusion in medical imagery and automated quality control and calibration are provided. In various embodiments, a medical image is received. The medical image includes a calibration target in its field of view. A description of the calibration target is read from the calibration target. The description includes size and at least one color reference. Based on the description of the calibration target, correction parameters are determined for the medical image. The correction parameters include pixel shape correction parameters, scale correction parameters, contrast correction parameters, or color correction parameters.