Invention Grant
- Patent Title: Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
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Application No.: US15112818Application Date: 2015-01-20
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Publication No.: US10537573B2Publication Date: 2020-01-21
- Inventor: Brian D. Klein , Hilde Lavreysen , Stefan Maria Christiaan Pype , Roy E. Twyman , Nancy Eulalie Sylvain Van Osselaer , H. Steven White , Marc André Ceusters , José Maria Cid-Núñez , Andrés Avelino Trabanco-Suárez , Roger Francis Bone
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP14153880 20140204; EP14153887 20140204; EP14183324 20140903; EP14187429 20141002
- International Application: PCT/EP2015/051029 WO 20150120
- International Announcement: WO2015/110435 WO 20150730
- Main IPC: A61K9/48
- IPC: A61K9/48 ; A61K45/06 ; A61P25/02 ; A61P25/06 ; A61P25/08 ; A61P25/18 ; A61K31/381 ; A61K31/437 ; A61K31/496 ; A61K31/506 ; A61K31/4015 ; A61K31/4545
Abstract:
The present invention relates to combinations comprising a positive allosteric modulator (“PAM”) of metabotropic glutamatergic receptor subtype 2 (“mGluR2”) or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof, and a synaptic vesicle protein 2A (“SV2A”) ligand.
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