Invention Grant
- Patent Title: Prohemostatic proteins for the treatment of bleeding
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Application No.: US15313881Application Date: 2015-05-26
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Publication No.: US10537618B2Publication Date: 2020-01-21
- Inventor: Daniël Verhoef , Pieter H. Reitsma , Mettine H. A. Bos
- Applicant: Academisch Ziekenhuis Leiden
- Applicant Address: NL Leiden
- Assignee: ACADEMISCH ZIEKENHUIS LEIDEN
- Current Assignee: ACADEMISCH ZIEKENHUIS LEIDEN
- Current Assignee Address: NL Leiden
- Agency: TraskBritt
- Priority: EP14169895 20140526
- International Application: PCT/NL2015/050377 WO 20150526
- International Announcement: WO2015/183085 WO 20151203
- Main IPC: A61K38/57
- IPC: A61K38/57 ; C07K14/745 ; A61K38/36 ; A61K38/16 ; A61K35/14 ; A61K38/00 ; C07K1/00 ; C07K14/00 ; C07K17/00 ; A61K38/48 ; C12N9/64
Abstract:
This disclosure relates to recombinant FXa polypeptides that can be used as antidotes to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor in a subject, preferably a direct factor Xa inhibitor. Disclosed herein are recombinant factor Xa proteins and a method of completely or partially reversing an anti-coagulant effect of a coagulation inhibitor in a subject.
Public/Granted literature
- US20170157223A1 PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING Public/Granted day:2017-06-08
Information query
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