Invention Grant
- Patent Title: Low concentration antibody formulations
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Application No.: US14775900Application Date: 2014-03-13
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Publication No.: US10537638B2Publication Date: 2020-01-21
- Inventor: George Crotts , Sorina Morar-Mitrica
- Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
- Applicant Address: GB Brentford, Middlesex
- Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
- Current Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
- Current Assignee Address: GB Brentford, Middlesex
- Agent Donald Huddler; Duke M. Fitch; Edward R. Gimmi
- International Application: PCT/IB2014/059757 WO 20140313
- International Announcement: WO2014/141152 WO 20140918
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K47/18 ; A61K47/26 ; A61K9/00
Abstract:
The present invention is directed formulations for low concentrations of therapeutic proteins and methods of making the same. In one aspect the present invention is directed to a formulation for a therapeutic protein comprising: a) the therapeutic protein; and b) a surfactant; wherein the molar ratio of surfactant to therapeutic protein is at least 100. In another aspect the present invention is directed to a formulation for a therapeutic protein comprising: a) the therapeutic protein; and b) an antioxidant, wherein the molar ratio of antioxidant to therapeutic protein is at least 750.
Public/Granted literature
- US20160000916A1 LOW CONCENTRATION ANTIBODY FORMULATIONS Public/Granted day:2016-01-07
Information query
