Invention Grant
- Patent Title: Covalent linkers in antibody-drug conjugates and methods of making and using the same
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Application No.: US15524487Application Date: 2016-08-15
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Publication No.: US10537644B2Publication Date: 2020-01-21
- Inventor: Chang Jiang Huang , Jianmin Fang , Hui Ye , Lezhi Zhang
- Applicant: RC Biotechnologies, Inc.
- Applicant Address: US CA Fremont
- Assignee: RC BIOTECHNOLOGIES, INC.
- Current Assignee: RC BIOTECHNOLOGIES, INC.
- Current Assignee Address: US CA Fremont
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/US2016/046987 WO 20160815
- International Announcement: WO2017/031034 WO 20170223
- Main IPC: A61K47/68
- IPC: A61K47/68 ; A61K31/44 ; C07D257/08 ; A61K47/54 ; C07K16/28 ; A61P35/00 ; C07K16/32
Abstract:
The present invention provides novel and advantageous compositions having a linker capable of covalently coupling one or more free thiols of an antibody. Specifically, provided herein are the molecular structures, synthetic pathways, coupling mechanisms, and applications thereof as used in an antibody-drug conjugate (ADC).
Public/Granted literature
- US20180055948A1 Covalent Linkers in Antibody-Drug Conjugates and Methods of Making and Using the Same Public/Granted day:2018-03-01
Information query
IPC分类:
