Invention Grant
- Patent Title: Inhibitors of arginase and their therapeutic applications
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Application No.: US15972996Application Date: 2018-05-07
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Publication No.: US10538537B2Publication Date: 2020-01-21
- Inventor: Michael Van Zandt , Adam Golebiowski , Min K. Ji , Darren Whitehouse , Todd Ryder , Raymond P. Beckett
- Applicant: Mars, Incorporated
- Applicant Address: US VA McLean
- Assignee: Mars, Incorporated
- Current Assignee: Mars, Incorporated
- Current Assignee Address: US VA McLean
- Agency: Foley Hoag LLP
- Agent David P. Halstead
- Main IPC: C07F5/02
- IPC: C07F5/02

Abstract:
Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.
Public/Granted literature
- US20180251479A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS Public/Granted day:2018-09-06
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