Invention Grant
- Patent Title: 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal FXR modulators
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Application No.: US15528331Application Date: 2015-11-19
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Publication No.: US10538550B2Publication Date: 2020-01-21
- Inventor: Alexander Weymouth-Wilson , Zofia Komsta , James Boydell , Laura Wallis , Rhys Batchelor , Carl Otter , Ieuan Davies
- Applicant: NZP UK LIMITED
- Applicant Address: GB Bristol
- Assignee: NZP UK Limited
- Current Assignee: NZP UK Limited
- Current Assignee Address: GB Bristol
- Agency: Morgan, Lewis & Bockius, LLP
- Priority: GB1420593.4 20141119; GB1420594.2 20141119; GB1505676.5 20150401
- International Application: PCT/GB2015/053518 WO 20151119
- International Announcement: WO2016/079519 WO 20160526
- Main IPC: C07J9/00
- IPC: C07J9/00
Abstract:
The invention relates to compounds of formula (I) wherein R1, R2, Y1, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acid derivatives with pharmacological activity. The invention further provides methods related to the synthesizing of these intermediates, and methods of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.
Public/Granted literature
- US20180340006A1 6.ALPHA.-ALKYL-3,7-DIONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR MODULATORS Public/Granted day:2018-11-29
Information query
