Invention Grant
- Patent Title: TCRS specific for minor histocompatibility (H) antigen HA-1 and uses thereof
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Application No.: US16362551Application Date: 2019-03-22
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Publication No.: US10538574B2Publication Date: 2020-01-21
- Inventor: Marie Bleakley , Robson Dossa , Daniel Sommermeyer
- Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
- Applicant Address: US WA Seattle
- Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
- Current Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
- Current Assignee Address: US WA Seattle
- Agency: Seed IP Law Group LLP
- Main IPC: C07K14/725
- IPC: C07K14/725 ; A61K35/17 ; C07K14/705 ; C12N5/0783 ; A61P35/02

Abstract:
The present disclosure provides compositions and methods for targeting a minor histocompatibility (H) antigen (HA-1H) to, for example, prevent or manage relapse of a hematological malignancy after allogeneic hematopoietic stem cell transplantation (HCT). Also provided are transgene constructs encoding engineered binding proteins, such as a T cell receptor or a chimeric antigen receptor, optionally encoding additional components such as a co-receptor and/or safety switch. Such transgene constructs can be transduced into an immune cell, such as a T cell, and used as an immunotherapy in a subject having a hematological malignancy or at risk for recurrence of the hematological malignancy (e.g., leukemia, lymphoma, myeloma).
Public/Granted literature
- US20190211076A1 TCRS SPECIFIC FOR MINOR HISTOCOMPATIBILITY (H) ANTIGEN HA-1 AND USES THEREOF Public/Granted day:2019-07-11
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