Invention Grant
- Patent Title: Mesothelin-targeted chimeric antigen receptors and methods of making them
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Application No.: US15981142Application Date: 2018-05-16
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Publication No.: US10538588B2Publication Date: 2020-01-21
- Inventor: Prasad S. Adusumilli , Michel Sadelain , Dimiter S. Dimitrov , Yang Feng
- Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER , The U.S.A. as Represented by the Secretary, Department Of Health and Human Services
- Applicant Address: US NY New York US MD Bethesda
- Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,THE U.S.A. AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,THE U.S.A. AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US NY New York US MD Bethesda
- Agency: Baker Botts L.L.P.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/725 ; C07K16/30 ; C07K14/705 ; C07K14/47 ; A61K39/00 ; A61K38/00 ; A61K35/00
Abstract:
The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.
Public/Granted literature
- US20180251546A1 MESOTHELIN-TARGETED CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF Public/Granted day:2018-09-06
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