A photonic crystal fiber according to the present invention has a plurality of holes arranged in the optical fiber along a longitudinal direction, in which the holes are arranged such that, in a cross section, a hole ratio which is an area of the holes per unit area is larger in a central side than in an outer side in a portion corresponding to a cladding and that a wide core area can be obtained while the number of modes that can be propagated is limited to several. Moreover, in a high-power optical transmission system according to the present invention, the amount of axis misalignment between the central axis of a laser oscillator and the central axis of the photonic crystal fiber is less than or equal to a certain amount.