As disclosed herein a method, executed by a processor, for accelerated instruction execution includes retrieving an execute instruction including a register reference and a reference to a target instruction, retrieving the target instruction, decoding the execute instruction using an instruction pipeline, decoding the target instruction using the instruction pipeline, associating the register reference to the target instruction, and executing the target instruction using the register reference as a source operand modifier. The instruction pipeline is configured such that it allows the target instruction to continue processing without waiting for the register reference to be resolved. The contents of the referenced register may be retrieved in a later stage of the instruction pipeline, and the target instruction may be modified and executed. An apparatus corresponding to the described method is also disclosed herein.