Systems and methods for synthesizing high resolution images using image deconvolution and depth information in accordance embodiments of the invention are disclosed. In one embodiment, an array camera includes a processor and a memory, wherein an image deconvolution application configures the processor to obtain light field image data, determine motion data based on metadata contained in the light field image data, generate a depth-dependent point spread function based on the synthesized high resolution image, the depth map, and the motion data, measure the quality of the synthesized high resolution image based on the generated depth-dependent point spread function, and when the measured quality of the synthesized high resolution image is within a quality threshold, incorporate the synthesized high resolution image into the light field image data.