The present invention concerns a system (S) for the detection and early warning of the incoming of acute events in patients with chronic obstructive pulmonary disease, comprising: at least one device (D) for the detection of physiological parameters (R), that can be applied to said patient to be monitored; at least one timer for detecting time intervals, such as date and time, associated with said detected physiological parameters (R); at least one emission device of sound and/or visual alarm signals capable of emitting an sound and/or visual output warning signal, associated with said physiological detected parameters (R); a control logic unit (C), connectable to said at least one device (D) and at least one timer, and capable of controlling said at least one emission signals device, suitable to receive in input said physiological detected parameters (R) and said time intervals, said control logic unit (C) being provided with a processing program, in which thresholds of predetermined values reached by said physiological parameters (R) are initially stored, which runs the following steps: associating said detected physiological parameters (R) with the time intervals, in which the detection has taken place; for every detection time instant, sending said physiological parameters (R) measured at a statistical indices calculation algorithm; comparing said statistical indexes obtained in the preceding step with said predetermined threshold and activating said at least one signals emission device for the emission of a sound and/or visual warning signal if at least one of said statistical indexes exceeds said corresponding predetermined threshold.