The present invention relates to a non-aqueous cosmetic composition comprising water-soluble scrub particles containing a polypeptide or a cell culture component. More specifically, the present invention relates to a non-aqueous cosmetic composition comprising 0.01 wt % to 15 wt % of hard and angulated water-soluble scrub particles containing cell culture components or various polypeptides including a peptide and an oligopeptide. Further, the cosmetic composition of the present invention provides a non-aqueous cosmetic composition which does not comprise active ingredients, but comprises water-soluble excipient scrub particles for maintaining or improving a scrubbing effect and adjusting viscosity or volume.