Invention Grant
- Patent Title: Polyplex of double-stranded RNA and polymeric conjugate
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Application No.: US16297133Application Date: 2019-03-08
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Publication No.: US10543232B2Publication Date: 2020-01-28
- Inventor: Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
- Applicant: TARGIMMUNE THERAPEUTICS AG
- Applicant Address: CH Basel
- Assignee: TargImmune Therapeutics AG
- Current Assignee: TargImmune Therapeutics AG
- Current Assignee Address: CH Basel
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61K47/34
- IPC: A61K47/34 ; A61K35/14 ; A61K45/06 ; C12N15/117 ; A61K47/60 ; A61K47/59 ; A61K35/17
Abstract:
A polyplex of a double stranded RNA (dsRNA) and a polymeric conjugate consists of a linear polyethyleneimine (PEI) covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety is conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. Exemplary cancer antigens include epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2) and prostate surface membrane antigen (PSMA).
Public/Granted literature
- US20190192563A1 POLYPLEX OF DOUBLE-STRANDED RNA AND POLYMERIC CONJUGATE Public/Granted day:2019-06-27
Information query
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