Systems and methods are disclosed that may be implemented to indicate real time availability of individual key assemblies for user input to an information handling system. In one embodiment, the disclosed systems and methods may be implemented to retract an individual key assembly of a user input device (e.g., such as keyboard matrix, game controller, game pad, computer mouse, etc.) when the key assembly is, or becomes, unavailable for input to a user application (e.g., such as a computer game) that is executing on a host programmable integrated circuit (e.g., such as host CPU) of an information handling system. Such a retracted key assembly may then be extended when it becomes available for input to the user application.