There is provided a depot suitable for sustained-release drug delivery, said depot including a composite body comprising particles having at least one encapsulated active pharmaceutical ingredient The depot includes 50 to 95 wt % of the composite body particles, said composite body particles having 0.1 to 80 wt % of active pharmaceutical ingredient, and the active pharmaceutical ingredient is a non-steroidal anti-inflammatory drug. In addition, the composite body is formed of a silica hydrogel comprising the silica particles.