Invention Grant
![(2R,4R)-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid](/docs/US/2020-02-04/US10548879B2/abs.jpg.600x600.jpg)
- Patent Title: (2R,4R)-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
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Application No.: US16207501Application Date: 2018-12-03
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Publication No.: US10548879B2Publication Date: 2020-02-04
- Inventor: Melissa Fleury , Adam D. Hughes , Anne-Marie Beausoleil , Erik Fenster , Venkat R. Thalladi , Miroslav Rapta
- Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Timothy R. Welch
- Main IPC: A61K31/421
- IPC: A61K31/421 ; C07D263/34 ; A61K9/48 ; A61K47/12 ; C30B7/14 ; C30B29/54 ; A61K45/06
![(2R,4R)-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid](/abs-image/US/2020/02/04/US10548879B2/abs.jpg.150x150.jpg)
Abstract:
In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.
Public/Granted literature
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