A pharmaceutical composition or dietary supplement with antagonist activity on the degradation and degeneration of cartilage tissue, anti-inflammatory and analgesic activity is described, which is effective in the treatment of arthropathies and osteoarthritis, comprising, as active ingredients, a combination of methylsulfonylmethane, unsaponifiables of avocado and/or soybean, and S-adenosyl-L-methionine.