Invention Grant
- Patent Title: Therapeutic compositions for neutralizing type I interferons, and methods of use
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Application No.: US15828582Application Date: 2017-12-01
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Publication No.: US10548946B2Publication Date: 2020-02-04
- Inventor: Joseph Golden , Jay Hooper
- Applicant: The United States of America, as represented by the Secretary of the Army, on behalf of the United States
- Applicant Address: US MD Fort Detrick
- Assignee: The government of the United States, as represented by the Secretary of the Army
- Current Assignee: The government of the United States, as represented by the Secretary of the Army
- Current Assignee Address: US MD Fort Detrick
- Agent Leigh Callander
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K39/275
Abstract:
The inventions describe here cover therapeutic compositions, and methods of use, for neutralizing Type I interferons in a mammal. The compositions contain a soluble Orthopoxvirus IFN-binding protein that is modified to remove the cell-binding region, and that specifically binds to Type I IFNs, and a pharmaceutically acceptable carrier or excipient. Another variation of the invention entails a novel IFN-binding protein that is modified to remove the cell-binding region and the signal sequence.
Public/Granted literature
- US20180110826A1 THERAPEUTIC COMPOSITIONS FOR NEUTRALIZING TYPE I INTERFERONS, AND METHODS OF USE Public/Granted day:2018-04-26
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