Invention Grant
- Patent Title: Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian H5N1 influenza
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Application No.: US15537109Application Date: 2015-12-18
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Publication No.: US10548965B2Publication Date: 2020-02-04
- Inventor: Ted Milburn Ross , Tim Alefantis , Donald Martin Carter , Christopher Austin Darby , Harold Kleanthous
- Applicant: Oregon Health & Science University , Sanofi Pasteur, Inc.
- Applicant Address: US OR Portland US PA Swiftwater
- Assignee: Oregon Health & Science University,Sanofi Pasteur, Inc.
- Current Assignee: Oregon Health & Science University,Sanofi Pasteur, Inc.
- Current Assignee Address: US OR Portland US PA Swiftwater
- Agency: MH2 Technology Law Group, LLP
- International Application: PCT/US2015/066890 WO 20151218
- International Announcement: WO2016/100926 WO 20160623
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A61K39/00
Abstract:
The present invention provides co-administration (e.g., immunogenic cocktail and/or prime-boost regimens) of computationally optimized H5N1 influenza hemagglutinin (HA) polypeptides that. Co-administration of the optimized H5N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to multiple H5N1 influenza virus clades and strains.
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