Invention Grant
- Patent Title: Gene-deleted variant strain of porcine pseudorabies virus, vaccine composition, method of making the same and use thereof
-
Application No.: US14901981Application Date: 2015-01-06
-
Publication No.: US10548972B2Publication Date: 2020-02-04
- Inventor: Kegong Tian , Xuke Zhang , Jinzhong Sun , Feifei Tan
- Applicant: Pulike Biological Engineering, Inc.
- Applicant Address: CN
- Assignee: PULIKE BIOLOGICAL ENGINEERING, INC.
- Current Assignee: PULIKE BIOLOGICAL ENGINEERING, INC.
- Current Assignee Address: CN
- Agency: Fish IP Law, LLP
- Priority: CN201410418379 20140822
- International Application: PCT/CN2015/070221 WO 20150106
- International Announcement: WO2016/026264 WO 20160225
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/00 ; A61K39/245 ; C12N7/04 ; A61K39/12 ; A61K45/06
Abstract:
The present invention provides an attenuated strain of porcine pseudorabies virus (PRV), in which said attenuated strain of PRV is a variant strain of PRV with inactivation of gI/gE/11K/28K proteins. In addition, the present invention also provides a vaccine composition comprising the attenuated strain of PRV as an antigen, a preparation method and use thereof. Proved by immunogenicity and pathogenicity testing of the live vaccine, said live PRV vaccine can provide a good protection for pigs with no clinical signs observed, indicating excellent immune protection.
Public/Granted literature
Information query
