Invention Grant
- Patent Title: Antibody-drug conjugates for targeting CD56-positive tumors
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Application No.: US15747620Application Date: 2016-07-29
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Publication No.: US10548987B2Publication Date: 2020-02-04
- Inventor: Dimiter S. Dimitrov , Yang Feng , John M. Maris , Zhongyu Zhu , Robyn Tovah Sussman
- Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services , The Children's Hospital of Philadelphia
- Applicant Address: US MD Bethesda US PA Philadelphia
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,The Children's Hospital of Philadelphia
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,The Children's Hospital of Philadelphia
- Current Assignee Address: US MD Bethesda US PA Philadelphia
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2016/044777 WO 20160729
- International Announcement: WO2017/023780 WO 20170209
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/00 ; A61K47/68 ; C07K16/28 ; A61P35/00 ; C07K16/30
Abstract:
The identification and characterization of two fully human CD56-specific monoclonal antibodies targeting spatially separated epitopes proximal and distal to the plasma membrane is described. Also described are antibody-drug conjugates (ADCs) of the identified antibodies and their use for targeting CD56-expressing tumor cells.
Public/Granted literature
- US20180214568A1 ANTIBODY-DRUG CONJUGATES FOR TARGETING CD56-POSITIVE TUMORS Public/Granted day:2018-08-02
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