Invention Grant
- Patent Title: Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries
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Application No.: US16113692Application Date: 2018-08-27
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Publication No.: US10549108B2Publication Date: 2020-02-04
- Inventor: Igor R. Efimov , Valentin Krinski , Vladmir P. Nikolski
- Applicant: Washington University
- Applicant Address: US MO St. Louis
- Assignee: The Washington University
- Current Assignee: The Washington University
- Current Assignee Address: US MO St. Louis
- Agency: Bookoff McAndrews, PLLC
- Main IPC: A61N1/36
- IPC: A61N1/36 ; A61N1/39 ; A61B5/0464 ; A61N1/362 ; A61B5/0402 ; A61B5/00

Abstract:
A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a relatively low voltage electric field in such a way as to effectively unpin the anatomical reentry. Preferably, the relatively low voltage electric field is defined by at least one unpinning shock(s) that are lower than an expected lower limit of vulnerability as established, for example, by a defibrillation threshold test. By understanding the physics of the electric field distribution between cardiac cells, the method permits the delivery of an electric field sufficient to unpin the core of the anatomical reentry, whether the precise or estimated location of the reentry is known or unknown and without the risk of inducting ventricular fibrillation. A number of embodiments for performing the method are disclosed.
Public/Granted literature
- US20190070424A1 Method for Low-Voltage Termination of Cardiac Arrhythmias by Effectively Unpinning Anatomical Reentries Public/Granted day:2019-03-07
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