The present invention is related to a flexible multilayer packaging film with high gas barrier properties comprising: one or more support layer(s) (1,10); one or more barrier layer(s) (6,60), each of the one or more barrier layer(s) (6,60) comprising an organic layer (2,20) and an inorganic layer(3,30); wherein said multilayer film has an oxygen transmission rate of less than 0.1 cm3/m2/24 h/atm, preferably less than 0.05 cm3/m2/24 h/atm, most preferably less than 0.03 cm3/m2/24 h/atm measured at 23° C. and 50% relative humidity.