Invention Grant
- Patent Title: Tetrahydroquinoline sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (t))
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Application No.: US15537591Application Date: 2015-12-18
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Publication No.: US10550110B2Publication Date: 2020-02-04
- Inventor: Branislav Musicki , Claire Bouix-Peter , Gilles Ouvry , Etienne Thoreau
- Applicant: GALDERMA RESEARCH & DEVELOPMENT
- Applicant Address: FR Biot
- Assignee: GALDERMA RESEARCH & DEVELOPMENT
- Current Assignee: GALDERMA RESEARCH & DEVELOPMENT
- Current Assignee Address: FR Biot
- Agency: Foley & Lardner LLP
- Agent Sunit Talapatra
- Priority: FR1463035 20141219; FR1556341 20150703
- International Application: PCT/EP2015/080690 WO 20151218
- International Announcement: WO2016/097392 WO 20160623
- Main IPC: C07D413/06
- IPC: C07D413/06 ; C07D405/14 ; C07D215/36 ; C07D231/56 ; C07D401/04 ; C07D401/06 ; C07D403/04 ; C07D403/06 ; C07D405/04 ; C07D405/12 ; C07D407/04 ; C07D409/04 ; C07D409/06 ; C07D417/06 ; C07D471/10 ; C07D209/34 ; C07D307/79 ; C07D405/06 ; A61P17/10 ; A61P17/06 ; A61P17/04 ; C07D401/14

Abstract:
Tetrahydroquinoline sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma (RORγt) are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of RORγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.
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