- Patent Title: Indole alkaloid compound having immune checkpoint inhibitory action
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Application No.: US16087947Application Date: 2017-03-24
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Publication No.: US10550120B2Publication Date: 2020-02-04
- Inventor: Haruhisa Kikuchi , Yoshiteru Oshima , Toshio Hattori , Osamu Yamada , Jing Zhang , Shinya Kida , Shinya Murase
- Applicant: TOHOKU UNIVERSITY , FUSO PHARMACEUTICAL INDUSTRIES, LTD.
- Applicant Address: JP Miyagi JP Osaka
- Assignee: TOHOKU UNIVERSITY,FUSO PHARMACEUTICAL INDUSTRIES, LTD.
- Current Assignee: TOHOKU UNIVERSITY,FUSO PHARMACEUTICAL INDUSTRIES, LTD.
- Current Assignee Address: JP Miyagi JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2016-062267 20160325
- International Application: PCT/JP2017/012157 WO 20170324
- International Announcement: WO2017/164407 WO 20170928
- Main IPC: C07D471/14
- IPC: C07D471/14 ; C07D401/06 ; C07D491/052 ; A61K39/39 ; A61P37/06 ; A61K39/00
Abstract:
The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R1, R1′, R2, R2′, R3-R8, and n are as defined in the present specification.
Public/Granted literature
- US20190092774A1 INDOLE ALKALOID COMPOUND HAVING IMMUNE CHECKPOINT INHIBITORY ACTION Public/Granted day:2019-03-28
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