Invention Grant
- Patent Title: Atropisomerism for increased kinase inhibitor selectivity
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Application No.: US15752128Application Date: 2016-08-15
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Publication No.: US10550124B2Publication Date: 2020-02-04
- Inventor: Jeffrey L. Gustafson , Davis E. Smith , David Hecht , Isaac Marquez , Sean Toenjes
- Applicant: SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION
- Applicant Address: US CA San Diego
- Assignee: San Diego State University Foundation
- Current Assignee: San Diego State University Foundation
- Current Assignee Address: US CA San Diego
- Agency: Haukaas Fortius PLLC
- Agent Michael H. Haukaas
- International Application: PCT/US2016/047085 WO 20160815
- International Announcement: WO2017/027883 WO 20170216
- Main IPC: C07D473/34
- IPC: C07D473/34 ; C07D487/04 ; A61P35/02
Abstract:
The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
Public/Granted literature
- US20180230154A1 ATROPISOMERISM FOR INCREASED KINASE INHIBITOR SELECTIVITY Public/Granted day:2018-08-16
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