Invention Grant
- Patent Title: Methods for the preparation of obeticholic acid and derivatives thereof
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Application No.: US16094535Application Date: 2017-04-18
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Publication No.: US10550146B2Publication Date: 2020-02-04
- Inventor: Benjamin List , Chandra Kanta De , Qinggang Wang
- Applicant: Intercept Pharmaceuticals, Inc.
- Applicant Address: US NY New York
- Assignee: Intercept Pharmaceuticals, Inc.
- Current Assignee: Intercept Pharmaceuticals, Inc.
- Current Assignee Address: US NY New York
- Agency: Intercept Pharmaceuticals, Inc.
- Agent Michelle Iwamoto-Fan
- International Application: PCT/US2017/028130 WO 20170418
- International Announcement: WO2017/184598 WO 20171026
- Main IPC: C07J9/00
- IPC: C07J9/00 ; C07J31/00
Abstract:
The present application relates to a safe method of preparing a bile acid derivative or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, on a large scale from 7-keto lithocholic acid (KLCA), comprising reacting Compound 2 with paraldehyde to form Compound 3 at a temperature between 10° C. and 30° C.:
Public/Granted literature
- US20190211052A1 METHODS FOR THE PREPARATION OF OBETICHOLIC ACID AND DERIVATIVES THEREOF Public/Granted day:2019-07-11
Information query
