Invention Grant
- Patent Title: PPAR agonists and methods of use thereof
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Application No.: US16022578Application Date: 2018-06-28
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Publication No.: US10550149B2Publication Date: 2020-02-04
- Inventor: Ronald M. Evans , Michael Downes
- Applicant: The Salk Institute for Biological Studies
- Applicant Address: US CA La Jolla
- Assignee: Salk Institute for Biological Studies
- Current Assignee: Salk Institute for Biological Studies
- Current Assignee Address: US CA La Jolla
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07K5/062 ; C07D309/04 ; C07D407/12 ; C07D271/12 ; C07D295/13 ; C07D213/40 ; C07D213/64 ; C07D307/68 ; C07D309/06 ; C07D231/12 ; C07D333/24 ; C07D401/04 ; C07D401/12 ; C07D405/04 ; C07D405/10 ; C07D405/12 ; C07D409/12 ; C07D413/04 ; C07D413/12 ; C07D417/04 ; C07D417/10 ; C07D417/12 ; C07C233/87 ; C07D205/04 ; C07D209/34 ; C07D295/155 ; C07D213/56 ; C07D305/06 ; C07D307/54 ; C07D307/81 ; C07D307/83 ; C07C255/57 ; C07C259/06 ; C07C233/73 ; C07C235/42 ; C07C235/48 ; C07C235/84 ; C07C237/32 ; C07C317/44 ; C07C233/75 ; C07D333/38
Abstract:
Provided herein are deuterated compounds and compositions useful in increasing PPARδ activity. The compounds have a formula where L5 comprises at least one deuterium. Exemplary species include The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
Public/Granted literature
- US20180305403A1 PPAR AGONISTS AND METHODS OF USE THEREOF Public/Granted day:2018-10-25
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