Invention Grant
- Patent Title: Oligomers for TNF superfamily inhibition, methods of making and using
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Application No.: US15894502Application Date: 2018-02-12
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Publication No.: US10550169B2Publication Date: 2020-02-04
- Inventor: Steven Teitelbaum , Daved Fremont , Julia T. Warren , Christopher Nelson
- Applicant: Washington University
- Applicant Address: US MO St. Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO St. Louis
- Main IPC: C07K14/52
- IPC: C07K14/52 ; C12N15/19 ; C07K14/705 ; A61K38/00
Abstract:
Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to engage or inhibit non-target TNF superfamily receptors, and methods of their use to treat diseases are provided. Single chain RANKL, TNF, and TRAIL ligands that effectively inhibit their target receptors while failing to inhibit non-target TNF superfamily receptors are also provided.
Public/Granted literature
- US20180312569A1 Oligomers for TNF Superfamily Inhibition, Methods of Making and Using Public/Granted day:2018-11-01
Information query
