Invention Grant
- Patent Title: Composition comprising a gene vector that selectively depletes P16 positive senescent cells
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Application No.: US16436265Application Date: 2019-06-10
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Publication No.: US10550378B2Publication Date: 2020-02-04
- Inventor: Serge Lichtsteiner , Nathaniel David
- Applicant: Unity Biotechnology, Inc. , Kythera Biopharmaceuticals, Inc.
- Applicant Address: US CA Brisbane US CA Calabasas
- Assignee: Unity Biotechnology, Inc.,Kythera Biopharmaceuticals, Inc.
- Current Assignee: Unity Biotechnology, Inc.,Kythera Biopharmaceuticals, Inc.
- Current Assignee Address: US CA Brisbane US CA Calabasas
- Agency: Wilson Sonsini Goodrich & Rosati
- Agent Janet Martineau
- Main IPC: C12N9/50
- IPC: C12N9/50 ; A61K38/48 ; C12N15/85
Abstract:
Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein. Other methods include expressing a pro-apoptotic gene in a senescent cell comprising administering to the cell the polynucleotide, virus, or pharmaceutical composition as described herein.
Public/Granted literature
- US20190316109A1 COMPOSITION COMPRISING A GENE VECTOR THAT SELECTIVELY DEPLETES P16 POSITIVE SENESCENT CELLS Public/Granted day:2019-10-17
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