- Patent Title: Monomers and oligonucleotides comprising cycloaddition adduct(s)
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Application No.: US15395221Application Date: 2016-12-30
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Publication No.: US10550386B2Publication Date: 2020-02-04
- Inventor: Muthiah Manoharan , Jayaprakash K. Nair , Kallanthottahil G. Rajeev , Michael E. Jung
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Cozen O'Connor
- Agent Jeffrey N. Townes
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D403/14 ; C12N15/113 ; C07F9/572 ; C07D249/16 ; C07D487/04 ; C07D493/04 ; C07D493/08 ; C07D495/04 ; C07D495/08 ; C07F9/655 ; C07F9/6558 ; C07H19/067 ; A61K31/7088 ; A61K31/711 ; A61K31/713
Abstract:
The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
Public/Granted literature
- US20170107513A1 MONOMERS AND OLIGONUCLEOTIDES COMPRISING CYCLOADDITION ADDUCT(S) Public/Granted day:2017-04-20
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